Kodi pali umboni wokwanira wothandizira kugwiritsa ntchito mankhwala owonjezerawa?
Zachilengedwe zomwe zingachepetse njala, 5-HTP (5-Hydroxytryptophan) ndi mankhwala a L-tryptophan, mtundu wa mapuloteni omwe amapezeka mu zakudya zambiri. Pogwiritsidwa ntchito ngati chithandizo cholemetsa , 5-HTP imachokera ku mbewu za chomera cha Griffonia simplicifolia .
5-HTP amadziwika kuti ikuwonjezera kupanga serotonin mu ubongo ndi pakatikati zamanjenje.
Mtundu wa khunyu (mankhwala omwe amachititsa kunyamula mauthenga pakati pa maselo a mitsempha), serotonin amathandiza kukonza chilakolako . Chifukwa chake, ena omwe akutsutsa mankhwala amanena kuti kumwa 5-HTP kungathandize kuchepetsa kulemera kwa kusunga chakudya chanu komanso kuchepetsa kudya kwanu.
Zimene Kafukufuku Amanena Ponena za Mapindu a 5-Hydroxytryptophan
Malingana ndi National Institutes of Health (NIH), palibe umboni wokhudzana ndi sayansi wokwanira kuti atenge zotsatira za kutenga 5-HTP zowonjezera kulemera kapena kunenepa kwambiri. Komabe, NIH imanena kuti kafukufuku wina wam'mbuyomu amasonyeza kuti 5-HTP ingathandize kuchepetsa kudya, kuchepetsa kudya kwa caloric, ndi kuchepetsa kulemera kwa anthu owonjezera.
Kafukufuku amene alipo ali ndi phunziro lakale kuyambira 1992 lofalitsidwa mu American Journal of Clinical Nutrition . Phunziroli, anthu okwana 20 omwe amapatsidwa mwayi wapadera amapatsidwa mwayi wokalandira 5-HTP kapena placebo kwa nthawi ya masabata awiri.
Ngakhale kuti palibe zakudya zomwe zinaperekedwa pa nthawi yoyamba yophunzira, zakudya zowonjezera zowonjezera zinavomerezedwa kwachiwiri. Zotsatira zaphunziro zinasonyeza kuti mamembala a gulu la 5-HTP anali ndi kulemera kwakukulu kwa nthawi zonse. Kuonjezerapo, mamembala a gulu la 5-HTP adachepetsanso kudya komanso zimakhala ndi chizoloŵezi chokhala ndi chizoloŵezi chokwanira.
Mufukufuku wina (wofalitsidwa mu International Journal of Obesity ndi Related Metabolic Disorders mu 1998), ofufuza adapeza kuti 5-HTP yachepetsa kwambiri kudya ma calories tsiku ndi tsiku komanso kuchepa kwa thupi la anthu akuluakulu odwala matenda a shuga. Phunziroli linaphatikizapo anthu 20 olemera kwambiri omwe ali ndi matenda a shuga a mtundu wa 2, omwe asanu ndi anayi omwe anapatsidwa 5-HTP ndi 11 omwe amapatsidwa malo a placebo.
Pali kusowa kwa kafukufuku waposachedwa pa mphamvu ya 5-HTP polimbikitsa kulemera kwa thupi.
Zingatheke Zovuta Zotsatira za 5-HTP
Malingana ndi NIH, kugwiritsidwa ntchito kwa mavitamini asanu ndi asanu (5-HTP) kungagwirizanitsidwe ndi eosinophilia-myalgia syndrome (EMS), vuto lalikulu limene limayambitsa kupweteketsa mtima kwambiri ndi magazi.
Mu 1989 ndi 1990, panali mliri wa EMS pakati pa anthu omwe adayambitsa L-tryptophan (chotsatira cha 5-HTP). Pambuyo pofufuza, mliriwo unachokera kumalo amodzi ndipo umatengedwa kuti uli ndi vuto chifukwa choyeretsedwa mwakachetechete kuphatikizapo ndondomeko yowonjezera yomwe imangotuluka kumene. Ngakhale kupanga malonda a 5-HTP sikugwiritsanso ntchito njira yotenthayo, NIH imalangiza kupewa kugwiritsa ntchito mavitamini 5-HTP mpaka zina zodziwika za chitetezo chawo.
Ndikofunika kukumbukira kuti zowonjezereka sizinayesedwe kuti zisawonongeke komanso zakudya zowonjezera zakudya sizingalekeke.
Nthaŵi zina, mankhwalawa amatha kupereka mankhwala omwe amasiyana ndi ndalama zomwe zimayikidwa pazitsamba iliyonse. Nthawi zina, mankhwalawa akhoza kuipitsidwa ndi zinthu zina monga zitsulo. Komanso, chitetezo cha mankhwala opatsirana mwa amayi apakati, amayi oyamwitsa, ana, ndi omwe ali ndi matenda kapena omwe akumwa mankhwala sanakhazikitsidwe.
5-HTP amadziwika kuti amayambitsa zotsatira zosiyanasiyana, kuphatikizapo:
- Kuthamangitsani
- Kupweteka kwa m'mimba
- Nausea
- Kuthamanga
- Kutsekula m'mimba
- Kugona
- Mavuto a kugonana
- Matenda a misampha
Kuyanjana kwa Mankhwala a 5-HTP
Komanso, kutenga 5-HTP kuphatikizapo mankhwala ena kungabweretse mavuto.
Mankhwalawa amatengera mankhwala osokoneza bongo (monga Prozac® ndi Zoloft®), dextromethorphan (Robitussin DM®, ndi ena), ndi meperidine (Demerol®). 5-HTP angagwirizanenso ndi zakudya zowonjezera, kuphatikizapo Wort St. John ndi S-adenosylmethionine.
Mukhoza kupeza malangizo othandizira kugwiritsa ntchito zowonjezerako apa.
Kugwiritsira ntchito 5-HTP ya Kutaya Kwambiri
Chifukwa cha nkhawa, NIH imalangiza kupewa kutenga 5-HTP mu mawonekedwe owonjezera. Kuonjezera apo, pali umboni wochepa wotsutsa zomwe akunena kuti 5-HTP yowonjezera ikhoza kuthandizira kulemera kwa thupi.
Ngati mukuganiza za kugwiritsa ntchito 5-HTP zowonjezera kulemera kwa thupi (kapena cholinga china chilichonse chokhudzana ndi thanzi), nkofunika kuwonana ndi wothandizira wanu musanayambe kulembetsa thupi lanu. Kudziletsa komanso kupewa kapena kuchepetsa kusamalidwa kosatha kungakhale ndi zotsatira zoopsa.
Zotsatira:
Bell SJ, Goodrick GK. "Chida chogwiritsidwa ntchito chothandizira kulemera kwa kulemera." Crit Rev Food Sci Nutriti. 2002 Mar; 42 (2): 163-78.
Cangiano C, Ceci F, Cascino A, Del Ben M, Laviano A, Muscaritoli M, Antonucci F, Rossi-Fanelli F. "Kudya komanso kutsatira malamulo okhudzana ndi zakudya za anthu akuluakulu omwe amachitira ndi 5-hydroxytryptophan." Am J Clin Nutr. 1992 Nov; 56 (5): 863-7.
Cangiano C, Laviano A, Del Ben M, Preziosa I, Angelico F, Cascino A, Rossi-Fanelli F. "Zotsatira za pakamwa 5-hydroxy-tryptophan pazochita zowonjezera mphamvu komanso zamagetsi m'magulu omwe sali odwala matenda a shuga." Int J Obes Relat Metab Disord. 1998 Jul; 22 (7): 648-54.
Hendricks EJ, Rothman RB, Greenway FL. "Akatswiri a feteleza kwambiri odwala amatha kugwiritsa ntchito mankhwala osokoneza bongo kuti athetse kunenepa kwambiri." Kunenepa kwambiri (Silver Spring). 2009 Sep; 17 (9): 1730-5.
National Institutes of Health. "5-HTP: Zowonjezerapo za MedlinePlus." May 2011.
Chodziwikiratu: Zomwe zili pa tsambali zimapangidwa pazinthu zophunzitsira zokha ndipo sizilowetsamo malangizo, matenda kapena chithandizo ndi dokotala wololedwa. Sichikutanthauza kubisa zonse zomwe zingatheke, kuyanjana kwa mankhwala, zochitika kapena zotsatirapo zoipa. Muyenera kupeza chithandizo chamankhwala mwamsanga pa nkhani iliyonse yathanzi ndikufunsani dokotala musanagwiritse ntchito mankhwala osakaniza kapena kusintha kwa regimen yanu.