Androstenedione (Andro) ndi mowonjezeretsa minofu yomwe mpira wa makamu Mark McGwire anapanga wotchuka. Koma kuyambira pachigamulocho, chakhala ngati anabolic steroid ndipo kotero, sikuletsedwa kugwiritsa ntchito popanda chifukwa choyenera cha mankhwala.
Komanso amatchedwa: 4-androstenedione kapena 4-androstene-3, 17-dione
Kodi Androstenedione Amatani?
Androstenedione wapangidwa kuchokera ku mahomoni a steroid mwachibadwa.
Mu thupi lanu, androstenedione ndi prohormone yopangidwa ndi adrenal glands, testes, ndi mavari. Thupi limagwiritsanso ntchito torostenedione mu testosterone , hormone yaikulu yamphongo, komanso ku estrogens estrone ndi estradiol. Pogwiritsira ntchito andro monga choonjezera chinali chovomerezeka, chinagwiritsidwa ntchito poyembekeza kukula kwa testosterone mu thupi. Kuwonjezera pa kupereka amuna ndi akazi makhalidwe a amuna, testosterone ili ndi zotsatira za anabolic, kukula kwa kukula kwa minofu ndi mphamvu.
Mankhwala a androstenedione angagwiritsidwe ntchito kuwonjezera ma testosterone a plasma. Kawirikawiri kafukufuku sanapeze alangizi a androstenedione kuti athe kuwonjezera mphamvu za testosterone. Kafukufuku wina adawonetsa kuti zotsatira zake ndizowonjezera mlingo wa estrogen mmalo mwake, ndipo analibe anabolic zotsatira pamatumbo mwa anyamata. Amagwiritsidwa ntchito ngati mankhwala owonjezera, omwe amawonetsanso kuti amakhala ndi zotsatira zoipa pochepetsa HDL cholesterol, zomwe zingakweretse mavuto amtundu wa mtima m'mabambo.
Androstenedione Gwiritsani ntchito masewera
Kwa zaka zambiri Major League Baseball sanalepheretse andro ngakhale umboni wakuti kugwiritsa ntchito kwake kungakhale koopsa kwa iwo omwe amautenga popanda chifukwa choyenera cha mankhwala. Anali ataletsedwa kale ndi Anti-Doping Agency, Komiti ya Olimpiki Yamayiko, NCAA, NFL ndi maulendo a amuna ndi azimayi a tennis.
Mu Januwale 2005, bungwe la Anabolic Steroid Control Act linasinthidwa ndi lamulo lolamulidwa lomwe linapanga anabolic steroid ndi prohormones ku mndandanda wa zinthu zowonongeka. Izi zimapangitsa kukhala ndi zinthu zomwezo ndizophwanya malamulo. Mu 2004, United States Food and Drug Administration (FDA) inaletsa kugulitsa kwa Andro, chifukwa cha umboni wothandizira kuonjezera chiopsezo cha umoyo pakugwiritsa ntchito mankhwalawa.
Chidziwitso cha FDA cha 54A, cha 9/15/2015, chimapereka chitsogozo kwa madera kuti zakudya zilizonse zowonjezereka ndi androstenedione, 4-androstenedione kapena 4-androstene-3, 17-dione akhoza kutsekeredwa popanda kusanthula. Kungolongosola mwachidule ndi chifukwa choletsera zolowera ku United States.
Zotsatira Zotsatira
Kafukufukuyu anaphatikizapo ngati zowonjezera zowonjezera zinkagwira ntchito zonse kuti zikweze ma teti testosterone, koma zinasonyezedwa kuti zili ndi zotsatira zolakwika ndikuwonjezera ngozi.
Ikhoza kugwirizana ndi owonda magazi monga Coumadin ndi salicylates. Ikhoza kugwirizananso ndi matenda a shuga monga sulfonylurea ndi insulini, amachepetsetsa magazi m'magazi. Zingayambitse mankhwala amphamvu kapena edema ngati atengedwa ndi corticosteroids.
Bungwe la US FDA White Paper pa zaumoyo za Androstenedione mu 2005 zinatchula mavuto omwe ankawopa kuti angachitike kwa ana ndi achinyamata omwe adatenga nthawi yayitali.
Izi zinaphatikizapo kuzimitsa anyamata ndi chiwerewere kwa atsikana. Kuyambira msinkhu usanafike msinkhu kungayambitse msinkhu.
Testosterone yowonjezereka mwa amuna achikulire angayambitse chiopsezo cha khansa ya prostate, komanso kukula kwa khansa ya chiwindi ndi khansa ya m'mawere amuna ndi akazi.
Zotsatira:
National Institute for Biotechnology Information. PubChem Compound Database; CID = 6128, https://pubchem.ncbi.nlm.nih.gov/compound/6128
US FDA; FDA White Paper Mavuto a Androstenedione. March 11, 2004
Thomson.Micromedex. Chidziwitso cha mankhwala kwa Health Care Professional. 25th ed. Vuto 1. Zowonjezera Zowonjezera. Zomwe Zasinthidwa ndi United States Pharmacopeial Convention, Inc. Greenwood Village, CO 2005., p. 142.