Kunenepa kwambiri kumapitirirabe kukhala mliri wochuluka womwe umakhudza akulu ndi ana. Malingana ndi National Institutes of Health, pakhala kuwonjezereka kofulumira kwa anthu omwe akuvutika ndi kulemera kwambiri kapena owonjezera kwa zaka 20 zapitazo. Matenda amadzimadzi akuwonjezereka kwambiri ndi omwe ali olemera kwambiri kapena olemera kwambiri. Matenda a kagayidwe kake ndi kagulu ka zinthu zoopsa zomwe zimapangitsa munthu kukhala ndi matenda a mtima ndi matenda.
Thandizo la Kunenepa Kwambiri
Kunenepa kwambiri ndi vuto la thanzi la padziko lonse lapansi lomwe limayambitsa kufufuza kosatha kuti apeze njira zochepetsera mafuta a thupi ndi matenda okhudzana ndi matenda. Kunenepa kwambiri komanso kukhala wonenepa kwambiri kumasonyeza kuti ndizo zifukwa zazikulu za matenda amadzimadzi. Kafukufuku wofalitsidwa ku National Institutes of Health wasonyeza chiwonetsero cha hop (ISHE), chowopsya cha mowa kuti athetse kudya kwambiri. Maphunziro omwe amapitirirabe akuphunzira apangidwa pa makoswe ndi anthu kutsimikizira izi.
Ziphuphu ndi Kutayika kwa Mafuta
Mphuno ndizomwe zimapangidwa mowa kwambiri ndi mowa mwachitsamba (humulus lupulus L.) . Isosidi m'mapangidwe amachititsa kuti mowa ukhale wokoma mtima. Kuwotcha ndi kusungirako kumapanga mgwirizano wochepa wowawa wotchedwa matured hop bitter acids (MHBA). MHBA imathandizidwa kuchepetsa kuchepetsa mafuta m'thupi mwa anthu ndi makoswe.
Matured hop acidic acid acids (MHBA) amatchedwa kuwonjezera thermogenesis (kutentha kwa thupi) m'thupi. Kutentha komwe kumapangidwa kuchokera ku thermogenesis kumawonetseredwa kuti kuonjezera mafuta oyaka ndi kuchepa kwa thupi. MHBA inanenedwa kuti iwonjezere mafuta odzola mu chiwindi ndi kuletsa kuyamwa mafuta m'matumbo. Mwakulankhula kwina, mafupa amawotchera ena mwa mafuta omwe sagwiritsidwa ntchito ku chiwindi komanso amalepheretsa kulowa mitsempha yathu.
Mphuno ndi Mafuta a Brown
Kafukufuku wofalitsidwa ku National Institutes of Health anayezetsa mavitamini a acyrus amphamvu (MHBA) pa makoswe. Cholinga cha phunziroli chinali kusonyeza MHBA kuchepetsa zakudya zomwe zimapangitsa kuti mafuta azigwiritsidwa ntchito pa makoswe komanso mbewa. Ochita kafukufuku anagwiritsira ntchito mafuta enaake omwe amatchedwa brown adipose minofu (BAT) panthawi yamavuto.
Brown adipose minofu (BAT) ntchito yoyamba ndiyo kupanga kutentha thupi. BAT ili ndi capillaries zambiri ndi lipids poyerekeza ndi maselo oyera. Chifukwa chakuti BAT imakhala yochuluka kwambiri imafuna mpweya wambiri. Mafuta a Brown amakhalanso ndi mitsempha yosakanikirana yopatsa mphamvu maselo olemera. Imodzi mwa ntchito za BAT imatipangitsa kuti tigwedezeke kuti tiwonjezere kutentha kwa thupi pamene tikuzizira. Mafuta a Brown amanenedwa kuti ndi chiwalo chothandizira kuchepetsa thupi.
Kafukufuku ndi Ndodo
Mavitamini okhwima okhwima (MHBA) anayesedwa pa makoswe omwe anapatsidwa zakudya zamatenda kuti apangitse kunenepa kwambiri. MBHA yasonyezeratu kuti ndibwino kwambiri mowa kuti zithandize kuchepetsa mafuta a thupi omwe amapezeka ku zakudya zosayenera.
Mphuno ndi mbewa zinkaphunziridwa pazitsulo zovuta zowunika kuchipatala. Nkhumbazo zinagawidwa m'magulu awiri onse akulandira zakudya zamtengo wapatali (HFD). Gulu limodzi linalandira mphamvu ya matenda akuluakulu otchedwa hop bittering acids (MHBA kapena MHB) kuwonjezera pa HFD yawo. MHB inalembedwa pang'onopang'ono mu gulu lolamulira pa masabata asanu ndi anayi. Kulemera kwa thupi kunayesedwa kawiri pa sabata poyesedwa. Magazi ndi zinyama zakunja zinatengedwa pamapeto a chiyeso.
Zotsatira za kafukufuku kuti mbewa zadyetsa mavitamini omwe amawomba mavitamini (MHBA kapena MHB) pamodzi ndi zakudya zamtengo wapatali (HFD) zinawonetsa phindu lolemera kwambiri. Ziwonetseranso kuti kuchepa kwa mafuta (white) adipose (mafuta) kunachepetsedwa komanso kudula mafuta omvera acids m'magazi. Zowonjezera zina zikuphatikizapo kuchuluka kwa mthenga wa ribonucleic acid (mRNA) omwe ndi chithunzi cha mapuloteni (kukula) . Zotsatira izi zimasonyeza kuti MHB imalimbikitsa kuwonjezeka kwa mRNA yeniyeni ya thermogenesis (yotentha) ya mafuta a bulauni.
Zotsatira za makoswe omwe amadya zida zowononga matayala (MHBA kapena MHB) ndi zakudya zamtengo wapatali zinkasonyeza kukula kwambiri kwa minofu ya adipose (BAT) komanso chifundo cha neural (SNA). Zimasonyezedwa kuti MHB imapangitsa kuti mitsempha yambiri ikhale yotsekemera yotulutsa thermogenesis (moto) wa mafuta ofiira.
Zotsatira zonsezi zikuwonetsa mavitamini okhwima omwe amawombera (MHBA kapena MHB) ngati othandizira kuwotcha mafuta a bulauni mu makoswe. MHB inasonyezedwanso kuti imathandizira kuwonjezeka kwa mafuta okhudzana ndi zakudya. Ngakhale kuti maphunziro ambiri akufunika, zikuwoneka kuti MHB ingakhale yowonjezera ku zakudya ndi zakumwa kuti "kuchepetsa kuwonjezeka kwa mafuta okhudzana ndi zakudya ndi zovuta zokhudzana ndi kusokoneza thupi ."
Anthu Ophunzira
Kafukufuku adafalitsidwa mu Nutrition Journal akufufuza momwe ziwowonjezera za matured zingachepetse mafuta a thupi mu anthu olemera kwambiri. Kafukufukuyu anaphatikizapo mazana awiri okwana amuna ndi akazi. Anthuwa anali pakati pa zaka 20 ndi 64 ali ndi chiwerengero cha thupi (BMI) cha 25 mpaka 30 makilogalamu / m² ndipo mwagawidwe anapatsidwa magulu awiri. Munthu aliyense anadwala CT scan m'mimba kuti awerenge mayesero apamimba, magazi ndi mkodzo monga gawo la pulogalamu yophunzira.
Pa nthawi yoyezetsa milungu khumi ndi iwiri, anthu amamwa mowa wokwana 350ml wokhala ndi mazira okhwima (MHE) pamodzi ndi odwala akuluakulu omwe amatha kudwala (MHBA) kapena maloboti. Zakumwa zogwira ntchito komanso zopanda ntchito zinawoneka ndikulawa chimodzimodzi. Zolemba zolondola za kudya, kuchita masewera olimbitsa thupi, ndi kuyamwa kwake kunasungidwa mu phunziro lonse. Zotsatira za thanzi labwino zinazindikiranso.
Zotsatira zapadera kwa gululo zakumwa zakumwa zochepetsera (MHE) zowonjezera (MHE) zakumwa zinawonetsa kuchepa kwakukulu kwa mafuta a m'mimba masabata asanu ndi atatu ndi khumi ndi awiri poyerekeza ndi olowa pamalo a placebo. Zotsatira zachiwiri kwa gulu lomwe likudya MHE zinali zazikulu zowonongeka ndi kupindula kwa chiwerengero cha misala ya thupi (BMI). Kuchepa kwa mafuta a chiŵerengero cha mafuta ocheperako ndibwino kwa iwo omwe amamwa MHE. Pambuyo pa masabata anayi, gululi likuonjezerapo ndi MHE kuzindikira chiuno chochepa ndi chiuno mofanana ndi olowa nawo. Anthuwa sankakhudzidwa ndi zotsatira zovuta zokhudzana ndi mayeso omaliza pa nthawi yofufuza.
Zowonjezera zowonjezera (MHE) zokhudzana ndi zomwe zapeza, sizikhala ndi mankhwala osowa okwanira kuti zitha kuwonjezera kunenepa kwambiri. Ochita kafukufuku anamaliza kumwa mowa wambiri wamadzimadzi (MHBA) m'kawotcherowo monga mankhwala omwe amalimbikitsa kutayika kwa mafuta . Kafukufukuyu adasonyeza kuti MHE pamodzi ndi 35mg MHBA zathandiza kuchepetsa mafuta a thupi. Phunziro lopitirira likufunika koma likuwoneka MHE akhoza kukhala "chida chothandiza ndi chotetezeka choletsa kunenepa kwambiri ndi matenda okhudzana ndi kagayidwe kachakudya."
Kodi Kumwa Mowa Kumapindulitsa Kwambiri?
Ngakhale mowa uli ndi mapulogalamu okhwima ndi ma-iso-asidi, sakhala ndi zotsatira zothandiza kuchepetsa mafuta amimba . Kotero, yankho la funso ili, ayi. Kuwonjezera pa zakumwa zazikuluzikulu za kalorizi zimakhudzana ndi kulemera komanso mavuto ena. Komanso, kafukufuku amene ali m'nkhaniyi anafufuza malo omwe ali kutali omwe ali ndi mowa.
Kodi Ilipo Mu Fomu Yowonjezera?
Mapiko okhwima amathandiza (MHA) agwiritsidwa ntchito mankhwala kwa zaka zambiri. Kafufuzidwe umasonyeza kuti MHA imathandizira kuti ikhale yosakondera komanso yogwiritsidwa ntchito monga antibacterial. Malinga ndi kafukufuku wofalitsidwa mu Molecular Nutrition ndi Food Research, akuluakulu akuluakulu acid hop acids amaletsa kutupa kwapadera kwapanyumba. MHA ikhoza kugulidwa ngati mankhwala osagwiritsidwa ntchito popanda mankhwala. Maphunziro a zachipatala akupitirirabe kuti azikhala okhwima okhwima amathandiza kuti azigwiritsidwa ntchito ngati mafuta oyaka mafuta kapena opondereza. Zotsatira za kafufuzidwe ndi zabwino ndipo zikuwoneka kuti mankhwala omwe amapezeka m'matope posachedwapa adzatengedwa ngati "mankhwala okhudzana ndi zakudya zamankhwala" omwe amathandizira matenda aakulu omwe amakhudzana ndi matenda amadzimadzi.
Zotsatira:
Biomed Central, Nutrition Journal, Kuchokera kwa Matured hop kumachepetsa mafuta a thupi m'thupi labwino kwambiri: gulu lopangidwa mozungulira, lopumphuka, lopanda mpweya, lomwe limagwiritsidwa ntchito limodzi, Yumie Morimoto-Kobayashi et al., 2016
Ma Institutes of Health, Abstract, Matured Hop Composents Induce Thermogenesis mu Brown Adipose Tissue kudzera Mwachisomo Ntchito, Morimoto-Kobayashi Y et al., 2015
Magazini Yapadziko Lonse Okhuta Kwambiri, Kupewa Kudyetsa Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chamakono
Ma Institutes of Health, Dipatimenti ya Zaumoyo ndi Zaumoyo za Anthu, Health Topics, Kodi Matendawa? 6/16
Chakudya Chamagulu ndi Kafukufuku wa Chakudya, Hop acac acid amavomereza bwino kutupa popanda GRalpha, PPARalpha, kapena PPARgamma, Van Cleemput M et al., 9/09