ZOKHUDZA ZOKHUDZA, Zotsatira Zotsatira ndi Zotsatira Zowoneka
Ngati mukufuna kuchepa thupi ndipo mukuyang'ana mankhwala ochepetsa kulemera kwa mankhwala , muli ndi zisankho zingapo. Dokotala wanu angakuuzeni za Belviq , Qsymia , Saxena kapena mankhwala ena otchedwa CONTRAVE (bupropion ndi naltrexone). Nazi zomwe muyenera kudziwa za CONTRAVE, kuphatikizapo ndalama, zotsatira zolemera, ndi zotsatirapo.
Kodi CONTRAVE ndi chiyani?
CONTRAVE ndi kuphatikiza mankhwala awiri osiyana: naltrexone hydrochloride ndi bupropion hydrochloride.
Pulogalamu iliyonse yotulutsidwa ili ndi:
- ma milligrams a naltrexone, a opioid agonist omwe nthawi zambiri amaperekedwa chifukwa chodalira mowa, kudalira opioid, kapena kusuta fodya mankhwala
- Mapulogalamu 90 a bupropion, aminoketone olekerera omwe amagwiritsidwa ntchito pochiza matenda ndi kuvutika kwa nyengo
Kuphatikiza kwa mankhwala awiriwa akulamulidwa kuti apangitse kulemera kwa kulemera. Mankhwalawa amakhudza dongosolo lanu lamkati la mitsempha kuti liwonjezere chiwerengero cha ma calories omwe mumayaka ndi kuchepetsa chilakolako chanu. Mapiritsiwa amalembedwa pamodzi ndi pulogalamu yochepetsera zakudya ndi machitidwe olimbitsa thupi kuti athandize anthu ena kulemera.
CONTRAVE imapangidwa ndi Orexigen ndipo imaperekedwa ndi Takeda.
Ndani Angatenge CONTRAVE?
CONTRAVE imavomerezedwa kuthandiza anthu okalamba omwe ali ndi chiwerengero cha thupi (BMI) cha anthu 30 kapena akulu kapena olemera kwambiri omwe ali ndi BMI ya 27 kapena akulu omwe ali ndi vuto limodzi lolemera monga cholesterol, mtundu wa shuga, kapena magazi kupanikizika.
Anthu ena sayenera kutenga CONTRAVE. Pewani mankhwala ngati:
- musamalamulire kuthamanga kwa magazi
- ali ndi matenda opatsirana, anorexia nervosa, kapena bulimia
- akumwa mowa mwauchidakwa kapena mankhwala ena (monga benzodiazepines, barbiturates, ndi antiepileptic mankhwala)
- akutenga mankhwala ena omwe ali ndi bupropion (monga Wellbutrin ndi Aplenzin)
- ndi wosagwiritsa ntchito opioid
- ali ndi pakati kapena akuyamwitsa
- sagwirizana ndi zinthu zina za CONTRAVE
Muyeneranso kutenga CONTRAVE mkati mwa masiku 14 mutatenga monoamine oxidase (hibitas) (MAOI).
Asayansi samadziwa momwe kutenga CONTRAVE kumakhudzira thanzi lanu la mtima la nthawi yaitali. Choncho ngati mwakhala pachiopsezo cha matenda a mtima, mungathe kuyankhula ndi dokotala wanu zomwe zingathe kuvulaza ngati mutenga mankhwalawa. Wopanga mankhwalawa akuchititsa maphunziro kuti awone momwe mapiritsi odyera amathandizira ndi thanzi labwino, koma zotsatira sizingayambe mpaka 2021.
Pomalizira, ofufuza samadziwa momwe COMPTRAVE imakhudzira zinthu zina zolemetsa ngati mankhwala, mankhwala osokoneza bongo, ndi mankhwala owonjezera. Onetsetsani kuti dokotala wanu adziwe ngati mutenga mankhwala ena kapena mankhwala osagwiritsidwa ntchito pamene mukukambirana ngati mankhwalawa ndi abwino kapena ayi.
ZOTHANDIZA Zotsatira za Kutaya Kwambiri
Malingana ndi kafukufuku wamakono, CONTRAVE ikhoza kuthandizira kulimbikitsa kulemera kwa thupi, koma nambala sizikudodometsa. Pofufuza odwala omwe alibe shuga, 42 peresenti ya odwala anataya pafupifupi 5 peresenti ya thupi lawo pambuyo pa chaka. Izi zikutanthauza kuti anthu ambiri omwe akutenga CONTRAVE sanakwaniritse zolinga zisanu.
Mu phunziro lina, 57 peresenti ya odwala omwe anatenga CONTRAVE ataya pafupifupi 5 peresenti ya thupi lawo. Koma azimayi 42 peresenti ya ophunzirawo adatuluka pulogalamuyo asanayambe kufufuza. Ambiri adatuluka m'masabata angapo oyamba.
Kwa odwala matenda a shuga, manambalawo ndi odzichepetsa. Odwala makumi atatu ndi asanu ndi mmodzi mwa anthu 100 alionse amadwala pafupifupi 5 peresenti ya kulemera kwa thupi pambuyo pa chaka. Mu maphunziro onse awiri (odwala omwe alibe matenda a shuga) gulu la placebo lomwe linatayika silinali lolemera kwambiri kuposa odwala omwe amagwiritsa ntchito CONTRAVE. Odwala onse m'magulu onsewa adalandira kusintha kwa moyo komwe kunali zakudya zochepa zowonjezera.
Ndiye kodi izi zikutanthauza chiyani kwa inu? Ndikofunika kukumbukira kuti mu phunziro lililonse, odwala omwe amagwiritsa ntchito CONTRAVE amakhalanso akusintha pa zakudya zawo ndi pulogalamu yawo yogonana. Kotero ngakhale kuti adataya kulemera kwake ndi mapiritsi odyetsa (pafupifupi mapaundi 12 pa chaka) zina za kulemera kwake zinali chifukwa cha kusintha kwa moyo (chakudya ndi masewera olimbitsa thupi) osati mankhwala.
Choncho, kuchuluka kwa kulemera kumene mumataya kungakhale kofunika kwambiri ndi momwe mungasamalire zakudya zathanzi, zakudya zokhudzana ndi kalori komanso masewera olimbitsa thupi.
MITU YA NKHANI ndi Zotsatira Zotsatira
Zotsatira zofala kwambiri zomwe odwala kutenga CONTRAVE zimaphatikizapo kunyoza, kudzimbidwa, kupweteka mutu, kusanza, chizungulire, kusowa tulo, pakamwa, ndi kutsekula m'mimba. M'mayesero a zachipatala, 24 peresenti ya anthu anasiya kutenga CONTRAVE chifukwa cha zotsatira. Anthu 12 peresenti ya anthu omwe amachotsa placebo anasiya mankhwala.
Kuphatikiza apo, phukusili likufunika kunyamula bokosi lakuda lakuda kuti owerenga ayenera kukhala osamala za chiopsezo chowonjezereka cha malingaliro odzipha ndi makhalidwe omwe ali achinyamata ndi achinyamata. Anthu omwe avutika ndi kupsinjika maganizo kapena kusokonezeka amatha kuona zinthu zawo kubwerera pamene zili pa CONTRAVE.
Popeza mankhwalawa avomerezedwa ndi a FDA, akatswiri ambiri azachipatala awonetsa kuti akudera nkhaŵa za kuthekera kwa ngozi ya mtima. Ena adandaula chifukwa cha malonda a pa TV omwe amachepetsa ngozi ndi zotsatira za CONTRAVE.
Zotsatira zake, mu 2017, bungwe la US Food and Drug Administration linachenjeza wogulitsa mankhwalawa kuti njira yomwe TV ikuwonetsedwera "imalepheretsa kuyankhulana kwa chidziwitso chofunika kwambiri ndipo potero kumasocheretsa zoopsa zomwe zimagwirizanitsidwa ndi kugwiritsa ntchito kusiyana" bungwe likupitiriza kunena kuti "Kuwonetserako mu kanema kuli vuto lalikulu makamaka kuchokera kuwonetsetsa za thanzi la anthu powapatsa ngozi zoopsa komanso zoopsa zowonongeka ndi mankhwala."
Ngati mutapeza malonda a kampaniyo ndikuganiza kuti mukutsatira CONTRAVE, onetsetsani kuti mumauza chithandizo chanu chaumoyo za mankhwala omwe mukuwutenga chifukwa pali zinthu zina zoopsa zomwe zingachitike ngati mankhwala ena akugwirizana nawo. Mutayamba kumwa piritsi yolemetsa, kambiranani ndi dokotala za zizindikiro zilizonse zachilendo. Pambuyo pa masabata 12 ngati simunataye osachepera 5 peresenti ya kulemera kwa thupi lanu, dokotala wanu adzasiya mankhwala anu ndi mankhwala omwe sizingatheke kuti mankhwalawa akugwirani ntchito.
ZOKHUDZA NDIPO
Chiwerengero cha mankhwala a CONTRAVE omwe mumatenga tsiku lirilonse amadziŵa mtengo wake wonse. Malingana ndi kufotokozera uthenga woperekedwa ndi kampaniyo, mlingo wanu umatha kusintha ngati mukupitirizabe kuchipatala.
Mukangoyamba kutenga CONTRAVE, mutha kumwa mapiritsi limodzi patsiku. Pamene mupitiriza kumwa mankhwala, mlingowo umawonjezeka. Pa sabata ziwiri, mutenga mapiritsi limodzi m'mawa ndi usiku. Pa sabata itatu, mumatenga mapiritsi awiri m'mawa ndi wina usiku. Pakatha masabata anayi, mlingowo ukhoza kuwonjezeka mpaka mapiritsi anayi patsiku, awiri m'mawa ndi awiri usiku.
Mudzapeza kuti mtengo wa CONTRAVE umasiyana ndi $ 99 pamwezi kupitirira $ 250 pamwezi malinga ndi mlingo, malo, ndi inshuwalansi. Wopanga mankhwalawa amapereka ndondomeko yotengera kuchotsera kwa odwala omwe inshuwaransi sichiphimba CONTRAVE kapena omwe alibe inshuwalansi. Ndi khadi lopulumutsa, simungathe kulipira ndalama zokwana madola 4 patsiku pamwezi.
Mawu Ochokera
Kulemera kwa thupi kungakhale kovuta. Piritsi la zakudya limakhala ngati yankho langwiro. Koma palibe mankhwala ochepetsa kulemera omwe amagwira ntchito bwino kwa aliyense. Lankhulani ndi dokotala wanu za zakudya zanu ndi zochitika zolimbitsa thupi ndi mbiri yanu yachipatala kuti mudziwe ngati CONTRAVE ikhoza kukuthandizani. Ngati mwasankha kupereka mankhwalawa, kambiranani ndi gulu lanu la thanzi labwino ngati muwona zizindikiro zosayembekezereka ndikukhala odzipereka kwambiri ku chakudya chopatsa thanzi komanso kuchita masewera olimbitsa thupi nthawi zonse kuti mukhale ndi thanzi labwino pamene mukuchepa. .
Zotsatira:
> Kupitiliza-Demo LL, Piccenna L, McNeil JJ. Pharmacotherapies for Obesity: Zakale, Zamakono, ndi Zamtsogolo Zamankhwala. Journal of Obesity . 2011; 2011: 179674. lembani: 10.1155 / 2011/179674.
> Sharfstein JM, Psaty BM. Kuunika kwa Mitsempha ya Mthupi ya Naltrexone-Bupropion: Phunziro Limasokonezedwa. JAMA. 2016; 315 (10): 984-6.
> Sherman MM, Rey JA. "Naltrexone / Bupropion ER (Yotsutsana): Njira Yothandizidwa Kwatsopano Kwambiri Kwa Odwala Matenda Osapitirira Mu Okalamba Aakulu". Pharmacy and Therapeutics 2016 Mar; 41 (3): 164, 166-168, 171-172.
> Utsogoleri wa US Food and Drug Administration. Makalata Ochenjeza ndi Mauthenga Otsutsana Malembo kwa Makampani Azachipatala. Orexigen Therapeutics, Inc. (Yotsutsana) Letesi Yopanda Dzina 5/18/2017