Zamoyo zathu, ndi zina, zimayang'ana momwe caffeine imakhudzira ife
Kuchepa kwa caffeine kumatanthawuza kuti kuchuluka kwa caffeine kumakhudza matupi athu. Anthu omwe ali ndi chidziwitso cha caffeine osadziwika akhoza kukhala ndi zizindikiro zazikulu - monga nkhawa, mantha, kupweteka mutu, kupweteka, ndi kusowa tulo - atatha kudya zakudya zazing'ono za caffeine, anthu omwe ali ndi mphamvu ya caffeine ayenera kuyesetsa kupeŵa caffeine kwathunthu.
Momwe munthu amavutitsira ndi kofiyine imatsimikiziridwa ndi zinthu zingapo kuphatikizapo zaka ndi kugonana, koma chinthu chachikulu ndizobadwa. Kwa amayi, kutengeka kwa caffeine kumayendetsedwa bwino ndi kugwiritsa ntchito njira za kulera, komanso ndi mimba.
Momwe Caffeine Imayendetsera Madzi
Caffeine imachokera mwamsanga m'matumbo kupita m'magazi, ndipo imadutsa mosavuta chiopsezo cha m'magazi mu ubongo. Amadutsanso mwaulere m'mimba mwa amayi apakati.
Mu ubongo, caffeine imamangiriza kwa adenosine receptors, motero kuteteza adenosine kuti asawakhudze. Chifukwa adenosine imatumiza ubongo kuti nthawi yogona, kutseka adenosine receptors amachititsa kuti akhale ogalamuka.
Caffeine imagwiritsidwa ntchito m'magazi ndi puloteni yotchedwa CYP1A2 kwa theophylline, paraxanthine ndi theobromine, ndipo imatulutsidwa ndi impso mu mkodzo. Theka la moyo wa caffeine amatha maola 4 mpaka 6, ndipo nthawi zambiri timakhala ndi nthawi yotani.
Kodi Chimakhudza Bwanji Kusuta kwa Caffeine?
Kukhalitsa mtima kwa caffeine kumadalira makamaka ntchito ya mankhwala a CYP1A2 m'chiwindi. Pamene yogwira CYP1A2 yogwira ntchito kwambiri, sitimvetsetsa kwambiri kuti tiyambe kumwa caffeine. Zinthu zambiri zimakhudza ntchito ya CYP1A2:
- Zaka: CYP1A2 ntchito ikucheperachepera ndi zaka, kotero anthu achikulire amayamba kukhala ochepetseka kwambiri ndi caffeine
- Kugonana: Amayi amakonda kukhala ndi ntchito yochepa ya CYP1A2 kuposa amuna.
- Kugwiritsira ntchito njira zothandizira pakamwa ndi mimba: ma estrojeni amaletsa ntchito ya CYP1A2, komanso kuchepa kwa caffeine kumawonjezeka
- Majini: Pali mitundu yambiri ya majini yomwe yakhala ikukhudza ntchito ya CYP1A2.
Chibadwa chathu ndi Chisamaliro cha Caffeine
Kuyeza kwa majeremusi kwatulutsa mitundu itatu yambiri ya kuchepa kwa caffeine yokhudzana ndi majini athu:
- Kusamalira Cafeine : Anthu awa ali ndi ntchito yotsika kwambiri ya CYP1A2. Adzakhala ndi mphamvu yolimbikira ngakhale pang'ono za khofi, ndipo kawirikawiri amadzakhala akuthawa komanso kusowa tulo.
- Sensitivity to Caffeine : Awa ndi ambiri mwa anthu. Amatha kudya 400 mg ya khofi patsiku popanda zotsatira zovuta.
- Kutsika Kwambiri kwa Caffeine : Anthu awa ali ndi ntchito yapamwamba kwambiri ya CYP1A2, ndipo nthawi zambiri sakhala ndi zotsatirapo konse kuchokera pakudya caffeine. Osuta fodya nthawi zambiri awonjezera ntchito ya CYP1A2.
Ngakhale kuyesedwa kwa majini kungakufotokozereni kuchuluka kwa mphamvu yanu ya caffeine, kuyesa kuyesa mwachidziwikire sikuli koyenera kuti mudziwe - makamaka kuyankhula - kaya muli ndi vuto la caffeine kapena ayi. Ndipo ngati muli, ndiye kuti palibe amene akuyenera kukuuzani kuti muchepetse.
Mimba ndi Chisamaliro cha Caffeine
Mimba moyenera imapangitsa kuti tizimva tizilombo toyambitsa matenda. Theka la moyo wa caffeine m'mayi oyembekezera nthawi zambiri amatha nthawi zinayi kusiyana ndi amayi omwe alibe amayi - nthawi zambiri mpaka maola 16. Kuwonjezera apo, kafeine imalowa mosavuta m'magazi - ndipo mwanayo ali ndi ntchito yaying'ono kwambiri ya CYP1A2. Ngakhale vuto lalikulu pa fetus lopangidwa chifukwa cha kudya kwa caffeine sikunatchulidwe, nkhaniyi siinaphunzire mozama. Kawirikawiri, amayi apakati ayenera kuchepetsa kapena kupeŵa caffeine.
> Zotsatira:
> Cornelis MC, Byrne EM, Esko T, et al. Consortium ya Coffee ndi Caffeine Genetics. Kusanthula kwa mchitidwe wamtunduwu kumatchula malemba asanu ndi limodzi omwe amapezeka ndi kachitidwe ka khofi. Psychiatry Molecular 20, 647-656 (May 2015) | lembani: 10.1038 / mp.2014.107
> Grant DM, Tang BK, Kalow W. Kusintha kwa mankhwala a caffeine. Clinical Pharmacology & Therapeutics, 33 (5), 591-602, 1983.
> Grosso LM, Bracken MB. Matenda a caffeine, ma genetic, ndi zotsatira zowonongeka: kubwereza kuunika kwa nthawi yomwe ali ndi mimba. Ann Epidemiol 2005; 15: 460.