Thandizo kwa Matenda a Neurological
Creatine ndi imodzi mwa zofufuzidwa kwambiri komanso zomwe zimagwiritsidwa ntchito kwambiri popititsa patsogolo minofu ndi mphamvu. Ndi otchuka pakati pa othamanga, omanga thupi ndi omwe akufuna kupanga masewera olimbitsa thupi. Creatine ikusonyezedwa kuti ndi imodzi mwa zabwino zowonjezera zowonjezera zowonjezera zowonjezera zokhudzana ndi masewera olimbitsa thupi . Ngakhale kuti akuwonetsetsa kuti kukula kwa minofu kukule bwino, umulungu umalangizidwanso kukhala wothandiza kwa iwo omwe akudwala matenda a ubongo.
Kafukufuku wamakono akupitiriza kuthandiza chithunzi chomwe chimagwira ntchito yopindulitsa m'katikati mwa mitsempha yapakati (CNS). Zikuwoneka kuti creatine supplementation akhoza kuchepetsa zizindikiro za matenda osokoneza bongo monga Alzheimer's, Parkinson's, ALS, ndi Huntington.
Kodi Creatine ndi chiyani?
Creatine ndi chinthu chachilengedwe chomwe chimapangidwa kuchokera ku amino acid glycine, arginine, ndi methionine. Amino acid ndizowonjezera mapuloteni. Creatine imapangidwa m'chiwindi, impso, ndi makoswe ndipo imayang'ana makamaka minofu ya minofu. Zing'onozing'ono zimagawidwa kudzera m'magazi athu kupita ku ubongo ndi ziwalo zina.
Creatine imapezedwanso m'zinthu zamapuloteni monga nyama ndi nsomba kuphatikizapo kupanga thupi.
Kodi Zimagwira Bwanji Thupi Lathu?
Creatine ili ndi udindo wopereka mphamvu ku maselo mkati mwa thupi ndi kusunga ntchito zathu zam'manja. Zimapezeka mwachibadwa ndipo zimaperekedwanso kudyetsa zakudya zina ndi zowonjezereka.
Pamene kulenga kumalowa kapena kumapangidwa ndi thupi, kumadutsa njira ya mankhwala ndikupanga phosphate . Molekyu yosungidwayi imapereka mphamvu yowonjezera ku maselo omwe atha kukhala atatha panthawi imene amayesetsa mwakuthupi kapena mwachangu.
Creatine phosphate imatchedwanso phosphocreatine (PCr). Creatine imapanga zolimbitsa thupi ntchito poonjezera kusungidwa PCr kapena ATP (adenosine tri-phosphate). ATP ndi gwero lina la magetsi limene limagwiritsidwa ntchito panthawi yofulumira yamagetsi ngati kupuma kapena kuponyera.
Phosphocreatine ndi malo osungirako mphamvu omwe amawathandiza kuti azichita masewera olimbitsa thupi. Ochita masewera amathandizira ndi Mlengi chifukwa amatha kupereka mphamvu ndikuwonjezera kukula kwa minofu.
Creatine yakhala yoposa maseŵera olimbitsa thupi . Kafukufuku wasonyeza kuti kulenga kuli ndi phindu lofunika pochiza matenda osokoneza bongo. Ndichidziwitso chothetsera mphamvu ya magetsi kumachepetsa zizindikiro za matenda a ubongo kwa odwala.
Zamoyo ndi Kafukufuku wa Nthenda
Malingana ndi kafukufuku wofalitsidwa mu Journal of Nelomolecular Medicine, chilengedwe chimatsimikiziridwa kukhala chithandizo chotheka kwa matenda a Huntington ndi Parkinson. Zikuwoneka kuti kulenga kumapangitsa kuti mphamvu za magetsi zisawonongeke m'magulu a ubongo kuchepetsa zizindikiro za matendawa.
Kafufuzidwe kafukufuku wothandizira nthawi yayitali yowonanso zotsatira zake zinachitidwanso. Odwala makumi asanu ndi limodzi okalamba anayesedwa kwa zaka 2 ndipo analandira 4g / d ya creatine kapena placebo. Cholinga chake makamaka chinali kutsimikizira ntchito yoyenera yothanzizira pokhapokha kuwonjezera pa kulenga kwa matenda a ubongo. Creatine inavomerezedwa kuti imalekerera odwala omwe akudwala matenda a Parkinson. Impso kapena ntchito yamphongo inalibe malire ndipo zotsatira zokhazokha zinkawoneka kuti zimakhumudwitsa nthawi zina.
Kafukufuku wina amasonyeza kuti ali ndi mphamvu yowonjezera kuti alingalire maganizo ndi kukumbukira anthu odwala komanso odwala matenda a Alzheimer's.
Kafukufuku wa Creatine anachitidwa pa odwala Lou Gehring Matenda. Matendawa amachititsa kuti matendawa asokonezeke kwambiri. Creatine inatsimikiziridwa kuti imapereka mphamvu ya mpweya.
Powonjezera, makina othandizira amaoneka kuti amapereka chitetezo cha mitsempha ya maselo. Kafukufuku wamakono amasonyeza kuti Mlengi akhale wothandizila wothandizira. Odwala omwe amagwiritsa ntchito kulenga amapeza bwino ntchito yamagalimoto komanso moyo wabwino.
Chiyembekezo cha Matenda a Edzi
Pakhoza kukhala chiyembekezo kwa odwala matenda a ubongo monga Parkinson's, Alzheimer's, Amyotrophic Lateral Sclerosis (ALS), ndi Huntington.
Creatine imawoneka kuti ikusewera gawo lofunika pokonza mphamvu zamagetsi. Kafukufuku wasonyeza zotsatira zowonjezera pofuna kuchepetsa kukula kwa matenda ena a ubongo.
Zikuwoneka kuti zikuwoneka kuti ndizowonjezera mphamvu ya kulenga monga njira yothandizira kuchiza matenda a ubongo. Zotsatira zabwino zimathandizira kufufuza kwina.
Matenda onse a ubongo amapereka mphamvu zosiyana za mphamvu zomwe zingapindule kapena zopindula ndi kulenga kowonjezera. Matenda a Alzheimer (AD) mwachitsanzo adapezeka kuti akuwonetsa bwino ndi supplementation pokhapokha pachiyambi. Pambuyo pake chithandizo cha AD sichinali chogwira ntchito chifukwa cha kulenga ndalama zomwe zimapezeka mu ubongo.
Pulojekiti ya Parkinson's (PD) imasonyeza kuti palibenso mphamvu zowonjezera kuti pang'onopang'ono pang'onopang'ono PD ipite patsogolo. Creatine imaoneka kuti ili ndi phindu la nthawi yaitali kwa anthu omwe panopa ali ndi PD.
Tsoka la Amyotrophic Lateral Sclerosis (ALS) mwatsoka komanso mofanana ndi matenda a Alzheimers (AD) sanayankhe mogwira mtima kuti alengeze zina.
Creatine supplementation inasonyeza kuti mungathe kuchiza matenda a Huntington (HD). Kafukufuku amasonyeza umboni wamphamvu womwe umalimbikitsa kulenga ngati wothandizira odwala matendawa. Cholengedwa chimatha kusintha komanso kuwonjezera moyo wa anthu omwe ali ndi HD.
> Zotsatira:
> Andreas Bender et al., Long-term creatine supplementation ndi otetezeka kwa okalamba omwe ali ndi matenda a Parkinson, Research Research , 2008
> Journal of Biomedicine ndi Biotechnology, National Library of Medicine, National Institutes of Health, The Creatine Kinase / Creatine Kulumikizana ndi Matenda a Alzheimer: CK Inactivation, COMP-CK Complexes, ndi Tanja S. Bürklen et al., 2006
> Official Journal of the American Academy of Neurology, neurology.org, PRECREST: Kuyesedwa kwachigawo chachiŵiri ndi chilengedwe cha chilengedwe cha mlengalenga ali pachiopsezo cha Huntington matenda, Herminia D. Rosas, MD et al., 3/11/14
> Official Journal of the American Academy of Neurology, neurology.org, mayesero osadziwika, aŵiri opunduka, osapindulitsa a chipatala cha creatine ndi minocycline m'kati mwa matenda a Parkinson, Dr. Bernard Ravina, 3/14/06
> National Library of Medicine, National Institutes of Health, Subcellular Biochemistry, Ntchito yothandizira anthu, Klein AM, Ferrante RJ, 2007